Squamous cell carcinoma is a common type of skin cancer. In the hand

area, this is the most common type; the most common location is the

dorsum of the hand. The hand area has complex anatomical characteristics

from ligaments, muscles, nerves, skin, and blood vessels, so treatment is

complex. Due to the complexity of the treatment, this article aimed to

describe the first case of skin cancer in the palm area that was treated with

radical surgery and a pedicled flap at the Oncology Center, Thai Nguyen

National Hospital. A 63-year-old male patient was admitted to the hospital

with a 2x3 cm tumor in the right palm; the tumor was ulcerated, secreted a

foul-smelling fluid, had limited mobility, was on an old surgical scar, and

invaded the surrounding skin tissue. The patient had a tumor biopsy and

was diagnosed with Squamous cell carcinoma T4N0M0. The patient

underwent wide excision of the tumor in the right-hand area, right axillary

lymph node dissection, and peripheral radial forearm flap. After surgery,

the disease progression was stable. With a diagnosis of T4N0M0 stage II

squamous cell skin cancer in the right-hand area, it is classified as having a

very high risk of recurrence. The patient was scheduled for postoperative

radiotherapy.