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A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch
Home Research Publications A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch

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A two-step design of experiments approach to investigate the simultaneous effects of ion-pairing and chemical enhancers to improve the permeability of lornoxicam in a topical hydrogel patch

Yen Dong Thi Hoang, Nguyễn Thạch Tùng, Jan-2024, In: Journal of Pharmaceutical Investigation, 54, p. 229-247

Overview

Abstract:

Abstract
A two-step experimental design was used to develop a lornoxicam (LOR)-loaded topical hydrogel patch. We
specifically focused on the simultaneous effect of the ion pair formation agent (triethanolamine [TEA]) and the chemical
enhancer (cremophor RH40 [RH40]) on flux and conducted physicochemical studies and skin physiology assessments to
obtain further information.

Keyword(s): Lornoxicam · Ion-pair · Chemical enhancer · Topical patch · Two-step design of experiments

Pages (from-to) 229-247
Journal Journal of Pharmaceutical Investigation
Volume 54
Publication status Published - Jan-2024
ISBN 2093-5552