Objectives: The aim of this study was to conduct a quantitative systematic review, including published data, comparing the efficacy of mineral trioxide aggregate as material used for the endodontic management of immature teeth. Methods: A systematic review of the intervention group using MTA, the control group using calcium hydroxide (Ca(OH)2). In subjects with imature permanent teeth because of necrotizing pulp disease or chronic apical periodontitis. Results: The time required for apical barrier formation of MTA group range from 1,35 ± 0,275 months to 3,0 ± 2,9 months while Ca(OH)2 group ranged from 1.95 ± 0.45 months to 7.93 ± 2.53 months. Apical barrier formation rate in the MTA group ranged from 7 to 29 teeth, in the Ca(OH)2 group range from 9 to 27 teeth. The clinical success rate of apical closure of teeth in the MTA group ranged from 90% to 100%. The clinical success rate in the control groups ranged from 73.30% to 93.33%. The radiographic success rate in the MTA group ranged from 82.4% to 100% but in the Ca(OH)2 groups ranged from 75% to 93.33%. Conclusion: both MTA and Ca(OH)2 materials have similar clinical success rate and radiographic success rates. However, the time required for apical barrier formation in this study of MTA was significantly shorter than that of Ca(OH)2.

Keywords: Immature permanent teeth, MTA, Apexification