Association of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with Alcohol abuse and Alcoholic Cirrhosis in People Living in Northeast Vietnam
, Huong Bui Thi Thu, Quang Viet Nguyen, , , , , , Jun-2023, In: Asian Pacific Journal of Cancer Prevention, 24, 6, p. 2073–2082
Overview
Abstract:
Objective: Alcohol abuse can cause developing cirrhosis, even liver cancer. Several single nucleotide polymorphisms
(SNPs) of ADH1B, ADH1C, and ALDH2 genes have been reported to be associated with alcohol abuse and alcoholic
cirrhosis (ALC). This study investigated the association between three SNPs of ADH1B rs1229984, ADH1C rs698, and
ALDH2 rs671 with alcohol abuse and ALC in people living in the Northeast region of Vietnam. Methods: 306 male
participants were recruited including 206 alcoholics (106 ALC, 100 without ALC) and 100 healthy non-alcoholics.
Clinical characteristics were collected by clinicians. Genotypes were identified by Sanger sequencing. Chi-Square
(χ2) and Fisher-exact tests were used to assess the differences in age and clinical characteristics, Child-Pugh score,
frequencies of alleles and genotypes. Result: Our data showed that the frequency of ALDH2*1 was significantly
higher in alcoholics (88.59%) and ALC groups (93.40%) than that of healthy non-alcoholics (78.50%) with p=0.0009
and non-ALC group (83.50%) with p=0.002, respectively. We detected opposite results when examined ALDH2*2.
Frequency of combined genotypes with high acetaldehyde accumulation were significantly lower in alcoholics and ALC
group than those of control groups with p=0.005 and p=0.008, respectively. Meanwhile, the proportion of combined
genotypes with non-acetaldehyde accumulation were significantly two times higher in the ALC group (19.98%) than
those of the non-ALC group (8%) with p=0.035. These combined genotypes showed a decreasing trend in the Child-
Pugh score from likely phenotype causing risk for non-acetaldehyde accumulation to high acetaldehyde accumulation.
Conclusion: The ALDH2*1 allele was found as a risk factor for alcohol abuse and ALC, and combined genotypes
of ADH1B rs1229984, ADH1C rs698, and ALDH2 rs671 with non-acetaldehyde accumulation increase ALC risk. In
contrast, ALDH2*2 and the genotype combinations related to high acetaldehyde accumulation were protective factors
against alcohol abuse and ALC.
Keyword(s): Alcohol metabolism genes- alcoholics- alcohol cirrhosis (ALC)- genetic polymorphism/variant
| Article number | 2073–2082 |
| Journal | Asian Pacific Journal of Cancer Prevention |
| Volume | 24 |
| Issue number | 6 |
| Publication status | Published - Jun-2023 |
| ISBN | 1513-7368 |