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Research / Publications
CHARACTERISTICS OF MAINTENANCE-PHASE TACROLIMUS TROUGH CONCENTRATIONS AND ASSOCIATED FACTORS IN KIDNEY TRANSPLANT RECIPIENTS AT THAI NGUYEN NATIONAL HOSPITAL
Home Research Publications CHARACTERISTICS OF MAINTENANCE-PHASE TACROLIMUS TROUGH CONCENTRATIONS AND ASSOCIATED FACTORS IN KIDNEY TRANSPLANT RECIPIENTS AT THAI NGUYEN NATIONAL HOSPITAL

CHARACTERISTICS OF MAINTENANCE-PHASE TACROLIMUS TROUGH CONCENTRATIONS AND ASSOCIATED FACTORS IN KIDNEY TRANSPLANT RECIPIENTS AT THAI NGUYEN NATIONAL HOSPITAL

T P. D. T., T T. T., May-2026, In: TNU Journal of Science and Technology, 231, 9, p. 459-465

Overview

Abstract:

The objective of this study is to describe the clinical characteristics, treatment regimens and maintenance-phase tacrolimus trough concentrations, and to identify factors associated with achieving the target tacrolimus range in kidney transplant recipients. A retrospective cross-sectional study was conducted in 42 outpatient kidney transplant recipients at Thai Nguyen National Hospital in December 2025. Factors associated with achieving the target tacrolimus range (4–7 ng/mL) were analyzed using the Chi-square test and Student’s t-test, with statistical significance set at p<0.05. The mean age was 40.21 ± 8.02 years, and 80.95% of patients were male. The most common immunosuppressive regimen was tacrolimus + mycophenolate mofetil + corticosteroid (92.86%). The median weight-based tacrolimus dose was 0.071 mg/kg/24 h, and the median tacrolimus trough concentration was 5.3 ng/mL (IQR: 4.2–6.1). Overall, 64.29% of patients were within the target range of 4–7 ng/mL. Post-transplant duration (p = 0.028) and donor source (p = 0.026) were the two factors significantly associated with achieving the target tacrolimus range

Keyword(s): Tacrolimus; Trough concentration; Kidney transplantation; Post-transplant duration; Donor source

Pages (from-to) 459-465
Journal TNU Journal of Science and Technology
Volume 231
Issue number 9
Publication status Published - May-2026
ISBN 1859-2171