Objectives: To describe clinical and bacteriological characteristics in sputum by quantitative culture method in patients with COPD exacerbation; Determine the relation of bacteriological results to clinical characteristics in patients with acute COPD. Methods: 118 patients were treated for acute COPD at Thai Nguyen Central Hospital. Descriptive research method. Results: The average age is 72.34 ± 9.77; Common symptoms in the study subjects were persistent dyspnea (54.2%); alveolar murmur decreased (89.0%); increased breathing rate (88.1%);27.7% of patients had positive sputum culture results. In which Haemophilus influenza accounts for the highest rate (30.3%). There is a correlation between sputum culture results and antibiotics before admission and fever symptoms of patients (p <0.05).