Objectives: Describe the characteristics of anti-HLA antibodies, the degree of HLA reconciliation and affect post-transplant renal function in kidney transplant patients at ThaiNguyen General Hospital. Subjects and research methods: Descriptive research methods with retrospective, research data of 21 kidney transplant pairs (donors and recipients) performed at Thai Nguyen Central Hospital from 2016 - 2019. Results: Harmony of HLA with 1 allele in HLA-A, HLA-B, HLA-DR accounts for the highest percentage, 01 complete pairing (all 6 alleles), harmonizing with 3 alleles the highest proportion (57,1%). Negative antibodies to HLA antibodies accounted for the highest rate of 57.1%, then positive for anti-HLA-A and B antibodies, accounting for 4.8%; 23,8 positive for anti-HLA-DR antibodies, DQ (19,0%); Renal function after transplantation tends to gradually stabilize, (p <0.05); Renal creatinine concentration tended to be better in couples with >3 alleles compared with the other group at the time after transplantation, (p <0.05); There is a positive correlation between the occurrence of anti-HLA antibodies and post-transplant creatinine levels at 2 weeks, 1 month and 12 months. Conclusion: Human leukocyte antigen (HLA) levels and the presence of anti-HLA antibodies are associated with post-transplant kidney function and the most basic tests in the selection of grafted and received pairs in kidney transplants. Choosing the right pair of pairing with the use of immunosuppressive drugs will increase the success rate of the transplant.