Economic evaluations of vaccines against respiratory infections in adults in Southeast Asia: A systematic review
Ba Khuong Cao, Lan Nguyen Thi Phuong, , , , Jun-2025, In: Human Vaccines and Immunotherapeutics, 21, 1, p. 2528409
Overview
Abstract:
Respiratory infections significantly impact adult health in Southeast Asia, yet vaccine
coverage remains low. This systematic review evaluated the economic evaluations of
vaccines targeting respiratory infections in the region. A comprehensive search was
conducted across several databases, including MEDLINE/PubMed, EMBASE, NHSEED,
CINAHL, EconLit, Web of Science, Scopus, and Cochrane Library, up to April 24, 2024.
Nineteen eligible studies were identified, focusing primarily on influenza (8 studies) and
COVID-19 vaccines (7 studies), with fewer studies on pneumococcal (2 studies), varicella
(1 study), and pertussis (1 study) vaccines. Overall, influenza, COVID-19 (boosters), and
pneumococcal vaccines were found to be cost-effective or highly cost-effective compared
to no-vaccine or no-booster scenarios. The only study on maternal pertussis
vaccination found it not to be cost-effective. The most common parameters considered
in sensitivity analyses were vaccine efficacy and discount rates. This review highlights the
economic evaluations of influenza, COVID-19, and pneumococcal vaccines in Southeast
Asia, providing essential evidence to guide vaccine policy. Future studies should address
limitations in model selection, incorporate herd immunity, ensure the model validation
(i.e. validity of cost and benefit measurements), and explore the cost-effectiveness of
other vaccines across the region.
| Article number | 2528409 |
| Journal | Human Vaccines and Immunotherapeutics |
| Volume | 21 |
| Issue number | 1 |
| Publication status | Published - Jun-2025 |
| ISBN | 2164-5515 |