EFFECTS OF SOME EXCIPIENTS AND DISPENSING TECHNIQUES ON THE DISSOLUTION RATE OF MELOXICAM TABLETS IN ENVIRONMENT PH 6.8
T T. P. T., H T. N. T., Nov-2018, In: Vietnam Medical Journal, 472, p. 551-562
Overview
Abstract:
This study was designed to evaluate the effect of some excipients and
dispensing techniques on dissolution rate of meloxicam tablets in environment pH 6.8. The meloxicam
tablets were prepared by wet granulation method. Prepared tablets were
evaluated for different quality criteria such as hardness, abrasion and
solubility. The different samples release the drug at intervals ranging from 5 to 30 minutes. The results
showed that the formulation
with 6% natri
croscarmelose and 1,4% Tween 80 had the fastest excipient release rate (83.87% within 15 min). The
combination of meloxicam in the excipient solution also results in
faster release of the drug.
Keyword(s): fast dissolving, meloxicam, wet granulation method
Pages (from-to) | 551-562 |
Journal | Vietnam Medical Journal |
Volume | 472 |
Publication status | Published - Nov-2018 |
ISBN | 1859-1868 |