Objectives: To find out the relationship between ophthalmopathywith some clinical, subclinical features, TRAb concentration in Graves desease. Subjects and methods: It including 82 patients with Graves' ophthalmopathy. They were admited at the National Hospital of Endocrinology.Research method was used a descriptive cross-sectional study. Results: Male were 3.72 times more likely to develop moderate to life-threatening ophthalmopathy disease than female. There was a relationship between TRAb and FT4 concentrations with the clinical activity of Graves' ophthalmopathywith OR 1.13 and 1.03, respectively, p < 0.01 and p < 0.05. Increased TRAb concentration was associated with exophthalmoson orbital computer tomography with OR 1.07, 95% CI from 1.02 to 1.13, p < 0.05. Conclusion: Men have a higher risk ofsevere ophthalmopathy disease than women. There was a relationship between TRAb concentration and Graves' ophthalmopathy.