The objectives of this study were to prepare topical gel containing lornoxicam for improved skin penetration of lornoxicam (LNX) for enhancement of its analgesic, anti-inflammation activity and to evaluate the impacts of different penetration enhancers on the in vitro diffusion of lornoxicam. The effect of addition of oleic acid, dimethyl sulfoxid (DMSO), l-menthol on physical properties of the gel and drug permeation was studied. The in-vitro diffusion studies showed a higher and faster release of lornoxicam from the gel containing DMSO than that from the gel containing oleic acid and l-menthol. DMSO exhibited enhanced permeation of lornoxicam from gel formulation. This work shows that lornoxicam can be formulated into Carbopol gel in presence of propylen glycol and polyethylen glycol as solvent, Carbopol as polymer and DMSO may be promising in enhancing permeation.