Objectives: To identify risk factors associated with neonatal hemorrhage at the Pediatric Center – Thai Nguyen National Hospital. Subjects and methods: The study included 139 neonates with hemorrhage (case group) and 278 neonates without hemorrhage (control group). A case-control study was conducted, with the case and control groups matched for gender and age. Results: The rate of neonatal hemorrhage in males is higher than in females, mainly

occurring in the first day after birth. Univariate analysis showed that factors increasing the risk of neonatal hemorrhage include: prematurity (OR=2.9, 95%CI:1.9-4.6), low birth weight (OR=2.2, 95%CI:1.5-2.4), asphyxia (OR=2.0, 95%CI:1.9-4.7), neonatal infection (OR=2.3, 95%CI:1.3-4.0), maternal gestational diabetes (OR=2.9, 95%CI=1.1-7.4), maternal hypertension (OR=7.1, 95%CI: 1.9-26.3).Multivariate analysis showed that preterm gestational age, infant asphyxia, neonatal infection, and maternal hypertension were independent factors increasing the risk of neonatal hemorrhage (p<0.05).