Abstract

STUDY OF ACUTE TOXICITY AND CHRONIC ANTI - INFLAMMATORY EFFECTS OF PANDANUS FRUITS IN EXPERIMENTS

Objectives:To estimate acute toxicology and evaluate chronic anti – inflammatory of of total extract (TE) and ethyl acetate extractect (EAE) of Pandanus odoratissimus L.f. fruits in experiments. Method: Acute toxicology was conducted based on method of Litchfield – Wilcoxon to calculate LD₅₀. Chronic anti-inflammatory effect was assessed through amiant- induced granuloma model in mice. Results: Acute toxicology : no acute toxicology was detected and LD₅₀ was not able to be calculated of  TE and EAE in mice. Chronic anti – inflammatory: TE and EAE extracted from Pandanus odoratissimus L.f. fruits with equivalent doses of 14.4g/kg  have chronic anti-inflammatory effects in experiments.