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Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings
Home Research Publications Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings

Synthesis and biological evaluation of novel phane-structured diazacrowns containing γ-piperidone and pyridine rings

Linh Nguyen Manh, Trần Thị Thanh Vân, Nguyễn Tiến Đạt, Hieu H. Truong, Victor N. Khrustalev, Sang T. Truong, Son T. Mai, Van T. Tran, Lê Tuấn Anh, Nov-2020, In: Mendeleev Communications, 30, 6, p. 753-755

Overview

  • Linh Nguyen Manh
  • Trần Thị Thanh Vân
  • Nguyễn Tiến Đạt
  • Hieu H. Truong
  • Victor N. Khrustalev
  • Sang T. Truong
  • Son T. Mai
  • Van T. Tran
  • Lê Tuấn Anh

Abstract:

Six novel phane-structured diazacrowns containing g-piperidone and pyridine rings were synthesized from podand 2,6-bis(2-formylphenoxymethyl)pyridine, with the g-piperidone moiety having been constructed in the course of its domino condensation with simple ketones and ammonium acetate. The compounds were tested in vitro for antimicrobial and cytotoxic activity against four human cancer cell lines (Hep-G2, RD, MCF-7, Lu-1) and the Vero cell line. X-Ray structure study of one representative compound revealed its rac-1RS,23SR,24RS,26SR configuration. 
Pages (from-to) 753-755
Journal Mendeleev Communications
Volume 30
Issue number 6
Publication status Published - Nov-2020
ISBN 0959-9436