Background: A cross-sectional descriptive study was conducted to assess the level of psychological stress and to analyze the factors influencing this psychological state during the clinical practicum - a critical period for the professional and personal development of nursing students. Objective: Describe the level of psychological stress and to analyze the factors influencing clincal stressor of nursing bachelor students. Subjects: Third- and fourth-year full-time nursing students of Thai Nguyen University of Medicine and Pharmacy. Methods: Cross-sectional descriptive design. Results: The highest proportion (64.5%) of full-time nursing students experienced a moderate level of psychological stress. The average psychological stress score among these students was moderate (82.14 ± 17.67). Factors significantly associated with psychological stress included gender, academic year, professional passion, academic performance, residence, financial support, expenditure level, physical exercise, recreational activities, and clinical practicum environment (p< 0.05). Conclusions: Full-time nursing students have mainly moderate levels of psychological stress, related to many personal and environmental factors, suggesting a need to improve safe and supportive learning and practice environments. The study recommends enhancing a safe, supportive, and friendly clinical practicum environment for nursing students.