Objectives: To translate and adapt the Diabetic Self-care Knowledge Questionnaire-30 (DSCKQ-30) questionnaire to be suitable for Vietnamese conditions and culture. To examine the reliability and validity of the Vietnamese version of the DSCKQ-30 questionnaire. 
Material and Methods: The questionnaire was forward translated, from English into Vietnamese and vice versa, by four independent translators. After that, an expert panel resolved any disagreements in translation regarding 4 criteria: semantics, idioms, experiences and concepts. The questionnaire then underwent a pilot study, on a sample of 100 DM patients to assess its clarity and readability; from June 1, 2021, to June 15, 2021. Finally, a test-retest study was conducted on a sample of 279 patients, over one month to examine internal consistency, stability and construct validity of the questionnaire; from July 1, 2021 to July 30, 2021. This study was approved by the Research Ethics Committee of the Thai Nguyen National Hospital. 
Results: The Vietnamese translated diabeté self-care knowledge questionnaire had content validity of 1.00, Cronbach’s alpha of 0.899 and Kappa coefficient of 0.700 or greater, except for question 15: with a Kappa coefficient of 0.658 (acceptable). 
Conclusion: The translated, adapted version of the DSCKQ-30 is valid, reliable and a feasible tool for practice, education and research in the future.